DART: Domain-Agnostic Residual Transfer for Generalist Anomaly Detection

Generalist Anomaly Detection (GAD) aims to detect anomalies in unseen domains using only a few reference samples. Recent normal-abnormal guided methods improve this setting by exploiting abnormal references, but their residuals often mix transferable anomaly cues with domain-specific appearance factors such as texture, geometry, and acquisition conditions. This residual domain entanglement limits cross-domain transfer and may produce spurious activations on novel domains. We propose DART, a plug-in framework for normal-abnormal guided GAD that learns to separate residuals into anomaly-relevant and domain-specific components. DART combines a Residual Disentanglement Module, which preserves anomaly-discriminative information while suppressing domain information, with Cross-Domain Meta-Training, which forms episodes across source domains to make the separation effective. The method is architecture-agnostic and can be inserted between residual computation and the detection head of existing GAD pipelines. Experiments on MVTec AD, VisA, and BraTS show consistent improvements over multiple base methods, with the largest gains under stronger domain shifts. https://github.com/aqeeelmirza/DART